PTGXProtagonist Therapeutics, Inc.

$143.75+131% 1Y

What is the market doing?

Mixed

No clear lean: nothing decisive, though heavily shorted (+12% of shares).

1 to watch, 2 neutral
TrendRangeboundderived · Oct 9, 2026

Choppy, but holding above its 200-day average. Price is +31% vs its 200-day average.

Insider conviction−$41.4M (90 days to Oct 8, 2026)SEC EDGAR · Oct 8, 2026

Insiders were net sellers over the 90 days ending Oct 8, 2026; selling is often routine (taxes, diversification).

Short interest12% of sharesFINRA · Sep 15, 2026

Heavily shorted, settled Sep 15, 2026, more than a week of normal trading to cover, a crowded exit.

Against the whole market›

Percentile against every name Ryufin tracks. Higher is better; the tick marks the middle of the market. Context, not one of the checks above.

1-year returntop 6% of the market
vs 200-day avgtop 9% of the market

Where this answer is blind. Insider selling is often routine (taxes, diversification); only cluster buying is a strong tell.

How PTGX is trading

Protagonist Therapeutics, Inc. is +131% over the past year while the S&P 500 is +18%: 113 points ahead of the market.

+131%

1-year return · S&P 500 +18%

vs 200-day average
+31%

vs 200-day average · a clear uptrend

RSI (14)
48

RSI (14) · neutral

Below its 52-week high
9.4%

Below its 52-week high

Sep 18, 2024$30.72 – $158.64 · dashed line: 200-day averageOct 9, 2026
Details›
Last close2026-10-09
$143.75
1 monthS&P 500 +2.7%
−0.94%
1 yearS&P 500 +18%
+131%
5 yearsS&P 500 +88%
+219%
vs 50-day average$145.19
−0.99%
52-week high
$158.63
52-week low
$64.00
Annualised volatility
57%
Insider buying, net, 6 monthsForms 3/4/5 to 2026-10-08
−$6.1M
Calendar-year price return
YearReturn
2026 (year to date)+65%
2025+126%
2024+68%
2023+110%
2022−68%
2021+70%
2020+186%
2019+4.8%
2018−68%
2017−5.4%
Average return by calendar month, 2016–2026
MonthYearsPositiveAverage
Jan106 of 10+3.1%
Feb105 of 10+0.49%
Mar105 of 10+7.8%
Apr102 of 10−12%
May107 of 10+19%
Jun108 of 10+11%
Jul106 of 10+1.4%
Aug108 of 10+15%
Sep115 of 11+0.06%
Oct115 of 11+3.8%
Nov106 of 10+7.7%
Dec105 of 10+1.4%

End-of-day closes from IEX; the S&P 500 comparison uses SPY over the same window. Prices are a reference point, not a basis for trading decisions.

On our screens:Most shorted stocks