IONSIonis Pharmaceuticals, Inc.
What is the market doing?
No clear lean: insiders net buying, but in a downtrend (−35% vs 200-day) and heavily shorted (+13% of shares).
In a downtrend, below its 50- and 200-day averages. Price is −35% vs its 200-day average.
Insiders were net buyers over the 90 days ending Oct 8, 2026.
Heavily shorted, settled Sep 15, 2026, about a week of normal trading to cover. Level with the previous count, up from 10.8% of shares outstanding three months ago.
Against the whole market›
Percentile against every name Ryufin tracks. Higher is better; the tick marks the middle of the market. Context, not one of the checks above.
Where this answer is blind. Insider selling is often routine (taxes, diversification); only cluster buying is a strong tell.
How IONS is trading
Ionis Pharmaceuticals, Inc. is −26% over the past year while the S&P 500 is +18%: 44 points behind the market. Through the fall, its own insiders bought $198K more stock than they sold.
1-year return · S&P 500 +18%
- vs 200-day average
- −35%
vs 200-day average · a clear downtrend
- RSI (14)
- 52
RSI (14) · neutral
- Below its 52-week high
- 48%
Below its 52-week high
Details›
- Last close2026-10-09
- $45.26
- 1 monthS&P 500 +2.7%
- −19%
- 1 yearS&P 500 +18%
- −26%
- 5 yearsS&P 500 +88%
- +25%
- vs 50-day average$52.74
- −14%
- 52-week high
- $86.50
- 52-week low
- $43.30
- Annualised volatility
- 48%
- Insider buying, net, 6 monthsForms 3/4/5 to 2026-10-08
- $198K
| Year | Return |
|---|---|
| 2026 (year to date) | −43% |
| 2025 | +126% |
| 2024 | −31% |
| 2023 | +34% |
| 2022 | +24% |
| 2021 | −46% |
| 2020 | −6.4% |
| 2019 | +12% |
| 2018 | +7.5% |
| 2017 | +5.2% |
| Month | Years | Positive | Average |
|---|---|---|---|
| Jan | 10 | 7 of 10 | +1.5% |
| Feb | 10 | 5 of 10 | −0.57% |
| Mar | 10 | 2 of 10 | −5.3% |
| Apr | 10 | 3 of 10 | +1.6% |
| May | 10 | 5 of 10 | −0.26% |
| Jun | 10 | 8 of 10 | +5.9% |
| Jul | 11 | 8 of 11 | +1.1% |
| Aug | 11 | 6 of 11 | +1.9% |
| Sep | 11 | 5 of 11 | +2.3% |
| Oct | 11 | 3 of 11 | −2.3% |
| Nov | 10 | 6 of 10 | +9.7% |
| Dec | 10 | 4 of 10 | +0.22% |
End-of-day closes from IEX; the S&P 500 comparison uses SPY over the same window. Prices are a reference point, not a basis for trading decisions.