SEPNSepterna, Inc.

$50.77+146% 1Y
Latest close: a new 52-week highNov 9, 2026what changed →

The business

How SEPN's business earns

Septerna, Inc. keeps −76% of every revenue dollar as operating profit, against −61% for the median Biotechnology name.

−76%

Operating margin · Biotechnology median −61% · 12 months to Sep 30, 2026

Share count, year on year
+2.9%

Share count, year on year · more shares than a year ago

Operating margin by fiscal year
Operating margin by fiscal year
YearOperating margin
FY20231374%
FY2024−7518%
FY2025−149%
Details›
Operating margin12 months to Sep 30, 2026
−76%
Net margin12 months to Sep 30, 2026
−61%
Free cash flow margin
−81%
R&D as % of revenue
138%
Revenue, trailing twelve months
$96M
Free cash flow, trailing twelve months
−$78M
Net income, trailing twelve months
−$59M

Margins, capital and share counts from the statements as filed with the SEC; cash conversion is operating cash flow over operating profit after tax.

Septerna (SEPN) Margins and Return on Capital · Ryufin