SYRESpyre Therapeutics, Inc.

$85.70+476% 1Y

Who owns SYRE

262 institutions reported holding SYRE for 2026Q2, together 122% of the company, more than the 195 a quarter earlier.

262

Institutions reporting a position · as of 2026Q2 · up from 195 the quarter before

Shares held by institutions
95.8M

Shares held by institutions · 122% of the company · long US equity positions only, as reported on Form 13F

Reported value
$8.52B

Reported value · at Jun 30, 2026 prices, not today's

Opened vs closed
89 / 24

Opened vs closed · new positions against positions exited in the latest quarter

Details›
Reporting quarter2026-06-30
2026Q2
Quarters on record
12
New positions
89
Positions exited
24
Added to
94
Reduced
54
Shares sold shortsettled Sep 15, 2026
12.1M
Short interestof shares outstanding
15%
Days to coverat the average daily volume
11.6
Change in the short positionsince the Aug 31, 2026 count
+2.3%
Institutional ownership by quarter, 2023Q3 to 2026Q2
QuarterFilersSharesReported value
2026Q226295.8M$8.52B
2026Q119582.5M$4.15B
2025Q415281.0M$2.65B
2025Q313564.3M$1.08B
2025Q212863.6M$953M
2025Q112862.1M$1.00B
2024Q412959.9M$1.39B
2024Q311951.4M$1.51B
2024Q210750.4M$1.18B
2024Q110231.6M$1.20B
2023Q45428.0M$601M
2023Q3263.3M$40M
Largest reported holders, 2026Q2
HolderShares% of companyValue
FMR LLC13.0Mn/a$1.16B
BlackRock Inc.6.5Mn/a$578M
VANGUARD GROUP INC6.4Mn/a$570M
PERCEPTIVE ADVISORS LLC4.3Mn/a$383M
RTW INVESTMENTS, LP4.3Mn/a$377M
Paradigm Biocapital Advisors LP3.8Mn/a$341M
STATE STREET CORP3.1Mn/a$271M
Venrock Adviser, LLC3.0Mn/a$265M
PRICE T ROWE ASSOCIATES INC /MD/3.0Mn/a$263M
Driehaus Capital Management LLC2.8Mn/a$249M
Short interest by settlement date, Aug 29, 2025 to Sep 15, 2026
SettlementShares shortOf shares outstandingDays to cover
Sep 15, 202612.1M15%11.6
Aug 31, 202611.9M15%9.7
Aug 14, 202611.8M15%15.9
Jul 31, 202612.1M15%13.5
Jul 15, 202612.5M16%9.0
Jun 30, 202613.6M17%5.6
Jun 15, 202612.6M16%10.8
May 29, 202612.6M16%15.5
May 15, 202612.4M16%10.4
Apr 30, 202612.2M16%10.0
Apr 15, 202611.7M15%7.3
Mar 31, 202610.4M13%11.5

SEC Form 13F data sets (DERA bulk files). 13F is quarterly, filed up to 45 days late, and covers long US equity positions only, no shorts, no derivatives, nothing held below the reporting threshold. The short position is FINRA's consolidated count for each twice-monthly settlement date, as a share of shares outstanding.

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