AZN vs NVS

AstraZeneca PLC and Novartis AG, both Healthcare

Novartis AG is the larger company at $281B against $271B. On trailing earnings NVS is the cheaper of the two at a P/E of 23.3 against 27.4, a gap that is only a bargain if the two are growing at similar rates. Over the past year NVS returned +40% against +13% for AZN. Ryufin's sector-relative Smart Score puts AZN ahead, 9/10 against 8/10.

AstraZeneca PLC and Novartis AGcompared on valuation, return and Ryufin’s Smart Score
FigureAZNNVS
Last close$166$158
Market cap$271B$281B
Trailing P/Elower is cheaper for the same earnings, not automatically better27.423.3
1-year return+13%+40%
5-year return+61%+106%
Ryufin Smart Scoresector-relative, 1–109/108/10

Figures from SEC filings and end-of-day closes. Highlighting marks the higher or lower number, which is not the same as the better investment, a low P/E can be a warning and a high one can be deserved.

AstraZeneca PLC

Revenue of $31B in H2 2025, net income $4.9B.

Novartis AG

Revenue of $27B in H2 2025, net income $6.3B.

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