AMGN vs AZN

Amgen and AstraZeneca PLC, both Healthcare

AstraZeneca PLC is the larger company at $271B against $182B. On trailing earnings AMGN is the cheaper of the two at a P/E of 27.4 against 27.4, a gap that is only a bargain if the two are growing at similar rates. Over the past year AMGN returned +59% against +13% for AZN.

Amgen and AstraZeneca PLCcompared on valuation, return and Ryufin’s Smart Score
FigureAMGNAZN
Last close$440$166
Market cap$182B$271B
Trailing P/Elower is cheaper for the same earnings, not automatically better27.427.4
Dividend yield2.2%n/a
1-year return+59%+13%
5-year return+113%+61%
Ryufin Smart Scoresector-relative, 1–109/109/10

Figures from SEC filings and end-of-day closes. Highlighting marks the higher or lower number, which is not the same as the better investment, a low P/E can be a warning and a high one can be deserved.

Amgen

Revenue of $10B in Q2 2026, net income $2.4B. Its largest reported line is Other Products, 17% of the disclosed total.

AstraZeneca PLC

Revenue of $31B in H2 2025, net income $4.9B.

Open these two in the interactive comparison to add more names, change the period or read the correlation.