ALNY vs VRTX

Alnylam Pharmaceuticals, Inc. and Vertex Pharmaceuticals, both Healthcare

Vertex Pharmaceuticals is the larger company at $115B against $37B. On trailing earnings VRTX is the cheaper of the two at a P/E of 31.9 against 121.3, a gap that is only a bargain if the two are growing at similar rates. Over the past year VRTX returned +42% against -45% for ALNY.

Alnylam Pharmaceuticals, Inc. and Vertex Pharmaceuticalscompared on valuation, return and Ryufin’s Smart Score
FigureALNYVRTX
Last close$239$547
Market cap$37B$115B
Trailing P/Elower is cheaper for the same earnings, not automatically better121.331.9
1-year return-45%+42%
5-year return+34%+171%
Ryufin Smart Scoresector-relative, 1–108/108/10

Figures from SEC filings and end-of-day closes. Highlighting marks the higher or lower number, which is not the same as the better investment, a low P/E can be a warning and a high one can be deserved.

Alnylam Pharmaceuticals, Inc.

Revenue of $2.5B in H1 2026, net income $370M. Its largest reported line is Amvuttra, 63% of the disclosed total.

Vertex Pharmaceuticals

Revenue of $3.3B in Q2 2026, net income $1.1B. Its largest reported line is TRIKAFTAKAFTRIO, 79% of the disclosed total.

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