ALNY vs ARGX

Alnylam Pharmaceuticals, Inc. and argenx SE, both Healthcare

argenx SE is the larger company at $55B against $37B. On trailing earnings ARGX is the cheaper of the two at a P/E of 53.5 against 121.3, a gap that is only a bargain if the two are growing at similar rates. Over the past year ARGX returned +56% against -45% for ALNY. Ryufin's sector-relative Smart Score puts ALNY ahead, 8/10 against 7/10.

Alnylam Pharmaceuticals, Inc. and argenx SEcompared on valuation, return and Ryufin’s Smart Score
FigureALNYARGX
Last close$239$1047
Market cap$37B$55B
Trailing P/Elower is cheaper for the same earnings, not automatically better121.353.5
1-year return-45%+56%
5-year return+34%+239%
Ryufin Smart Scoresector-relative, 1–108/107/10

Figures from SEC filings and end-of-day closes. Highlighting marks the higher or lower number, which is not the same as the better investment, a low P/E can be a warning and a high one can be deserved.

Alnylam Pharmaceuticals, Inc.

Revenue of $2.5B in H1 2026, net income $370M. Its largest reported line is Amvuttra, 63% of the disclosed total.

argenx SE

Revenue of $2.5B in H2 2025, net income $877M.

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