XBIvsXLV

State Street SPDR S&P Biotech ETF or State Street Health Care Select Sector SPDR ETF, side by side from their own SEC filings. 6.3% of their stock holdings are the same at the same weight, across 8 stocks in both. XLV costs 0.08% a year against 0.35% for XBI, $27 a year less on $10,000. Over the last twelve months XBI returned +91.7% and XLV +19.8%.

6.3%of the two portfolios is the same stocks at the same weight
XBI8.5% in stocks the other holds too
XLV18% in stocks the other holds too
stocks in bothstocks only in that fundbonds, cash and unmatched shares

The two funds

From each fund's latest N-PORT filing and its prospectus.

XBIXLVYearly cost0.35%0.08%Net assets$10.7B$40.6BPositions16165Last 12 months+91.7%+19.8%3 years, a year+24.1%+7.9%5 years, a year+3.3%+6.4%Largest holdingState 5.9%LLY 16.5%Main sectorHealthcare 94%Healthcare 100%Holdings as ofJun 30, 2026Jun 30, 2026

Returns are total returns with dividends reinvested, from the funds’ own monthly figures; “(price)” marks a fund whose filing record is younger than a year, whose twelve months are its price change. The stronger figure in each row is set in bold. Past returns say what happened, not what will.

Growth of $100

Both funds from July 2019, the first month both report, dividends reinvested.

XBI$182XLV$193
July 2019June 2026

What they both hold

8 stocks are in both funds: 8.5% of XBI and 18% of XLV. The biggest shared positions:

Stockin XBIin XLV
VRTX1.1%2.2%ABBV1.0%7.7%AMGN1.0%3.4%GILD1.0%2.7%REGN1.0%1.1%BIIB1.0%0.6%MRNA1.4%0.4%INCY1.0%0.3%

Only in XBI

Its biggest stocks the other fund does not hold.

  1. TWSTTwist Bioscience Corporation1.4%
  2. ORKAOruka Therapeutics, Inc.1.4%
  3. KYMRKymera Therapeutics, Inc.1.4%
  4. VKTXViking Therapeutics, Inc.1.3%
  5. PRAXPraxis Precision Medicines, Inc.1.3%
  6. ERASErasca, Inc.1.3%

Only in XLV

Its biggest stocks the other fund does not hold.

  1. LLYEli Lilly16.5%
  2. JNJJohnson & Johnson10.6%
  3. UNHUnitedHealth Group6.6%
  4. MRKMerck & Co.5.5%
  5. TMOThermo Fisher Scientific3.2%
  6. ABTAbbott Laboratories2.8%

More comparisons

IBB vs XBIIWO vs XBIVHT vs XBIVBK vs XBIIWM vs XBIVHT vs XLVHDV vs XLVVIG vs XLV

From each fund’s Form N-PORT (XBI: June 2026, XLV: June 2026) and prospectus, via the SEC’s public data sets. Overlap counts only the stocks we can match to a listing: stock by stock, the smaller of the two weights, added up.