IBBvsXBI

iShares Biotechnology ETF or State Street SPDR S&P Biotech ETF, side by side from their own SEC filings. 40% of their stock holdings are the same at the same weight, across 113 stocks in both. XBI costs 0.35% a year against 0.44% for IBB, $9 a year less on $10,000. Over the last twelve months IBB returned +50.6% and XBI +91.7%.

40%of the two portfolios is the same stocks at the same weight
IBB74% in stocks the other holds too
XBI81% in stocks the other holds too
stocks in bothstocks only in that fundbonds, cash and unmatched shares

The two funds

From each fund's latest N-PORT filing and its prospectus.

IBBXBIYearly cost0.44%0.35%Net assets$9.1B$10.7BPositions252161Last 12 months+50.6%+91.7%3 years, a year+14.7%+24.1%5 years, a year+3.3%+3.3%Largest holdingBlackRock 12.0%State 5.9%Main sectorHealthcare 97%Healthcare 94%Holdings as ofJun 30, 2026Jun 30, 2026

Returns are total returns with dividends reinvested, from the funds’ own monthly figures; “(price)” marks a fund whose filing record is younger than a year, whose twelve months are its price change. The stronger figure in each row is set in bold. Past returns say what happened, not what will.

Growth of $100

Both funds from July 2019, the first month both report, dividends reinvested.

IBB$177XBI$182
July 2019June 2026

What they both hold

113 stocks are in both funds: 74% of IBB and 81% of XBI. The biggest shared positions:

Stockin IBBin XBI
MRNA2.0%1.4%RVMD2.8%1.2%NTRA2.9%1.2%ROIV1.4%1.2%INSM1.8%1.1%VRTX8.1%1.1%BIIB2.5%1.0%IONS1.0%1.0%INCY1.7%1.0%AMGN7.8%1.0%

Only in IBB

Its biggest stocks the other fund does not hold.

  1. ARGXargenx SE3.8%
  2. ILMNIllumina, Inc.2.1%
  3. ONCBeOne Medicines AG1.8%
  4. ASNDAscendis Pharma A/S1.3%
  5. GMABGenmab A/S1.1%
  6. MEDPMedpace Holdings, Inc.1.0%

Only in XBI

Its biggest stocks the other fund does not hold.

  1. VKTXViking Therapeutics, Inc.1.3%
  2. SLSSELLAS Life Sciences Group, Inc.1.2%
  3. DNTHDianthus Therapeutics, Inc.1.2%
  4. CELCCelcuity Inc.1.1%
  5. TGTXTG Therapeutics, Inc.1.1%
  6. ABBVAbbVie1.0%

More comparisons

IBB vs VHTIBB vs IWOIBB vs VBKIBB vs XLVIWO vs XBIVHT vs XBIVBK vs XBIIWM vs XBI

From each fund’s Form N-PORT (IBB: June 2026, XBI: June 2026) and prospectus, via the SEC’s public data sets. Overlap counts only the stocks we can match to a listing: stock by stock, the smaller of the two weights, added up.