ONC vs VRTX

BeOne Medicines AG and Vertex Pharmaceuticals, both Healthcare

Vertex Pharmaceuticals is the larger company at $129B against $40B. Over the past year VRTX returned +32% against +3.8% for ONC.

BeOne Medicines AG and Vertex Pharmaceuticals compared on valuation, return and the RyuScore
FigureONCVRTX
Last close$351$507
Market cap$40B$129B
Trailing P/Elower is cheaper for the same earnings, not automatically bettern/a29.5
1-year return+3.8%+32%
5-year return-6.6%+169%
RyuScoresector-relative, 1–10n/a57/100

Figures from SEC filings and end-of-day closes. Highlighting marks the higher or lower number, which is not the same as the better investment, a low P/E can be a warning and a high one can be deserved.

BeOne Medicines AG

Vertex Pharmaceuticals

Revenue of $3.3B in Q2 2026, net income $1.1B. Its largest reported line is TRIKAFTAKAFTRIO, 75% of the disclosed total.

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