AXSM vs IONS

Axsome Therapeutics, Inc. and Ionis Pharmaceuticals, Inc., both Healthcare

Axsome Therapeutics, Inc. is the larger company at $13B against $12B. Over the past year AXSM returned +99% against +54% for IONS.

Axsome Therapeutics, Inc. and Ionis Pharmaceuticals, Inc.compared on valuation, return and Ryufin’s Smart Score
FigureAXSMIONS
Last close$207$63.37
Market cap$13B$12B
1-year return+99%+54%
5-year return+312%+68%
Ryufin Smart Scoresector-relative, 1–109/109/10

Figures from SEC filings and end-of-day closes. Highlighting marks the higher or lower number, which is not the same as the better investment, a low P/E can be a warning and a high one can be deserved.

Axsome Therapeutics, Inc.

Revenue of $218M in Q2 2026, net income null. Its largest reported line is Royalty And Milestone, 66% of the disclosed total.

Ionis Pharmaceuticals, Inc.

Revenue of $268M in Q2 2026, net income null. Its largest reported line is Royalty, 28% of the disclosed total.

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