AXSM vs EXEL

Axsome Therapeutics, Inc. and Exelixis, Inc., both Healthcare

Exelixis, Inc. is the larger company at $13B against $13B. Over the past year AXSM returned +99% against +50% for EXEL. Ryufin's sector-relative Smart Score puts AXSM ahead, 9/10 against 8/10.

Axsome Therapeutics, Inc. and Exelixis, Inc.compared on valuation, return and Ryufin’s Smart Score
FigureAXSMEXEL
Last close$207$56.07
Market cap$13B$13B
Trailing P/Elower is cheaper for the same earnings, not automatically bettern/a18.6
1-year return+99%+50%
5-year return+312%+225%
Ryufin Smart Scoresector-relative, 1–109/108/10

Figures from SEC filings and end-of-day closes. Highlighting marks the higher or lower number, which is not the same as the better investment, a low P/E can be a warning and a high one can be deserved.

Axsome Therapeutics, Inc.

Revenue of $218M in Q2 2026, net income null. Its largest reported line is Royalty And Milestone, 66% of the disclosed total.

Exelixis, Inc.

Revenue of $611M in Q1 2026, net income $210M. Its largest reported line is Product Gross, 87% of the disclosed total.

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