DGX vs ILMN

Quest Diagnostics and Illumina, Inc., both Healthcare

Illumina, Inc. is the larger company at $25B against $22B. On trailing earnings DGX is the cheaper of the two at a P/E of 27.1 against 42.0, a gap that is only a bargain if the two are growing at similar rates. Over the past year ILMN returned +136% against +44% for DGX. Ryufin's sector-relative Smart Score puts ILMN ahead, 7/10 against 6/10.

Quest Diagnostics and Illumina, Inc.compared on valuation, return and Ryufin’s Smart Score
FigureDGXILMN
Last close$245$225
Market cap$22B$25B
Trailing P/Elower is cheaper for the same earnings, not automatically better27.142.0
1-year return+44%+136%
5-year return+90%-53%
Ryufin Smart Scoresector-relative, 1–106/107/10

Figures from SEC filings and end-of-day closes. Highlighting marks the higher or lower number, which is not the same as the better investment, a low P/E can be a warning and a high one can be deserved.

Quest Diagnostics

Revenue of $2.9B in Q1 2026, net income $252M. Its largest reported line is Diagnostic Information Services Business, 98% of the disclosed total.

Illumina, Inc.

Revenue of $1.2B in Q2 2026, net income $207M. Its largest reported line is United States And Canada, 54% of the disclosed total.

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